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Posters
 

Development of iPSC-derived Alzheimer Disease (AD) platforms for phenotypic screening

      A Murchison1, P Zhou1, C Noel1, D Haag1, J Wu1, T Huang1, and W Poon1,2, NeuCyte, Inc., CA

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Characterization of an in vitro synaptic propagation assay using iPSC-derived neurons and multiwell microelectrode array technology

      D Millard, D Sullivan, r Hayes, Axion BioSystems, GA

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The electrophysiological responses to antibacterial drug in human iPSC-derived neurons demonstrate the claissification of antibacterial drugs encephalopathy in clinical

      Yuto ISHIBASHI, Kazutoshi OGAWA, and Ikuro SUZUKI, Tohoku Institute of Technology, Japan

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Establishing an In Vitro Assay for Predicting Neurotoxicity Risks Using Functional Human iPSC-Derived Neurons

      H Liu, W Zhong, L Saavedra, T Portmann, J Davila, D Haag, and T Huang, NeuCyte Inc., CA

 

In Vitro Neurotoxicity Testing Using Functional Human iPSC-Derived Neurons

      H Liu1, L Saavedra1, K Wallace2, T Freudenrich2, T Portmann1, J Davila1, TJ Shafer2, M Wernig3, and D Haag1
1 NeuCyte Inc., CA, 2 US EPA, 3 Stanford University, CA

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Development of a Fully Defined, Synaptically Competent iPSC-Derived Neuronal Platform for Drug Discovery

      L Saavedra, Vu Cao Dang, A Fua, and J Davila, and D Haag, NeuCyte Inc., CA

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New iPSC-Based Neural In Vitro Approach for Seizure Liability Testing

      L Saavedra, A Fua, V Dang, J Davila, and D Haag, NeuCyte Inc., CA

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Comparison of Acute Effects of Neurotoxic Compounds in Neural Networks from Rodent and Human Neurons Using Microelectrode Arrays

      T Freudenrich1, K Wallace1, D Haag2, L Saavedra2, M Mall2 , WR Mundy1, J Davila2, TC Südhof3, M Wernig2, and TJ Shafer1
1 US EPA, 2 Stanford University, CA

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Application of Patient Generated iPSCs-Derived Neurons to Define the Pathophysiology of FXS Neurons

      S Botelho , L Saavedra, A Fua, T.Huang, J Dávila, D Haag, V Dang, NeuCyte Inc., CA

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Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures

      L Saavedra2,4, K Wallace1, T Freudenrich1, M Mall2, WR Mundy1, J Davila2,4, TC Südhof3, TJ Shafer1, M Wernig2, and D Haag2,4
1US EPA, 2 Stanford University, CA, 3 Stanford University, CA, 4 NeuCyte Inc., CA

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Functional Characterization of Neural Network Activity in Human iPSC-Derived Neuron/Glial Co-cultures

      T Molla, C Lee, P Zhou, W Zhong, L Saavedra, J Dávila and D Haag,  NeuCyte Inc., CA

Relevant Publications
 

1. Pediaditakis, I., et al., A Microengineered Brain-Chip to Model Neuroinflammation in Humans, iSCIENCE 2022

 

2. TCW, et. al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. June 2022

 

3. H. Zaer, et. al. Non-Ablative Doses of Focal Ionizing Radiation Alters Function of Central Neural Circuits. Brain Stimulation. Apr 2022

 

4. L. Saavedra, et. al. Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures. Toxicol Sci. Feb 2021

 

5. A. Tukker, et. al. Towards Animal-Free Neurotoxicity Screening: Applicability of hiPSC-Derived Neuronal Models for In Vitro Seizure Liability Assessment. ALTEX, 37(1): 121-135, 2020

 

6. Soscia, D. et al. A flexible 3-dementional micro electrode array for in vitro brain models. Lab Chio, 20:901-911, 2020

 

7. Zhang, Y. et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron, 78(5): 785-98, 2013

 

8.  Yang, N et al. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods, 14(6): 621–628, 2017

 

9. Pak, C. et al. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell, 17(3): 316-28, 2015

 

10. Yi, F. et al. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science,

352(6286): aaf2669, 2016