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Establishing an In Vitro Assay for Predicting Neurotoxicity Risks Using Functional Human iPSC-Derived Neurons

In Vitro Neurotoxicity Testing Using Functional Human iPSC-Derived Neurons

Development of a Fully Defined, Synaptically Competent iPSC-Derived Neuronal Platform for Drug Discovery

New iPSC-Based Neural In Vitro Approach for Seizure Liability Testing

Comparison of Acute Effects of Neurotoxic Compounds in Neural Networks from Rodent and Human Neurons Using Microelectrode Arrays

Application of Patient Generated iPSCs-Derived Neurons to Define the Pathophysiology of FXS Neurons

Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures

Functional Characterization of Neural Network Activity in Human iPSC-Derived Neuron/Glial Co-cultures

Our MEA work is enabled by Axion Biosystem's Technology

Webinars

Building Confidence in Neurotoxicity Testing Using an In Vitro Phenotypic Assay Platform Based on Human iPSC-Derived Neurons

Beyond iPSC Based Disease Models- A Translatable Drug Discovery Platform for Status Epilepticus

Assessing the Suitability of iPSC-Based Neural In Vitro Assays for Neurotoxicity Testing

Screening for Enviromental Toxins with a Human Brain in a Dish Model

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User Guide and Protocols

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SynFire protocol with Axion MEA system

SynFire protocol with AlphaMED MED64 MEA system

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Publications on or with Our Core Technology

1. Soscia, D. et al. A flexible 3-dementional micro electrode array for in vitro brain models. Lab Chio, 20:901-911, 2020.

2. Zhang, Y. et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron, 78(5): 785-98, 2013.

3. Yang, N et al. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods, 14(6): 621–628, 2017.

4. Pak, C. et al. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell, 17(3): 316-28, 2015.

5. Yi, F. et al. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science, 352(6286): aaf2669, 2016.